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Despite headline-grabbing clinical results (up to 22% weight loss in trials), studies show average weight reduction in routine care is typically 28% after a year, with only about one third of patients achieving greater than 5% loss

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This doesnt necessarily mean that HRT boosts semaglutides efficacy, the study authors proposed, but rather that not receiving HRT may weaken the post-menopausal bodys response to semaglutide