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Awad NS, Paul V, AlSawaftah NM, ter Haar G, Allen TM, Pitt WG, et al
Quality matters when it comes to injectable peptides -- and the right pharmacy makes all the difference
The codes are outlined in Table 3
The oral small-molecule inhibitor INCB001158 (CB-1158), targeting this axis, has entered first-inhuman phase I studies and has been explored in combination with PD-1 inhibitors, suggesting that relieving substrate depletion-driven immunosuppression is clinically feasible from a safety and pharmacodynamic perspective, although its therapeutic efficacy remains to be fully established (116)
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