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By blocking sodium-glucose co-transporter-2 in the kidneys, they promote glucose excretion through urine, effectively lowering blood sugar levels
The gradual dose escalation protocol recommended for Saxendastarting at 0.6 mg daily and increasing weekly by 0.6 mg increments to the maintenance dose of 3.0 mgis specifically designed to improve gastrointestinal tolerability, as per the UK SmPC
& Weiss, G
Type 1 diabetes induces cognitive dysfunction in rats associated with alterations of the gut microbiome and metabolomes in serum and hippocampus
Anytime you have a higher dose of a medication, more side effects are likely, she explains
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