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Glutathione-S-transferase genes and asthma phenotypes: A Human Genome Epidemiology (HuGE) systematic review and meta-analysis including unpublished data
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But if enzymatic function is impaired, nutrient cofactors are deficient, or toxins/ microbial byproducts inhibit pathways, these can become blocked, causing abnormal organic acid buildup in urine
Studies suggest that the VEGF/VEGFR-2 pathway may be particularly relevant, as its activation seems to trigger intracellular signaling cascades that potentially influence endothelial cell migration, proliferation, and survival
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