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6 Department of molecular genetic, University Hospital, Grenoble, France Correspondence: Delphine Gobert ([email protected]) Allergy, Asthma & Clinical Immunology 2025, 21(Suppl 2) :P-04 Background: Hereditary angioedema caused by mutation of factor XII (HAE-FXII) accounts for 20 to 25% of HAE with normal C1-inhibitor

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a few percent develop high titers which might reduce efficacy ( [105] ) ( [108] )

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