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This limit is directly tied to telomere shortening: once telomeres become critically short, cells stop dividing

All three expanded MACE events consisted of hospitalizations for heart failure, each occurring in a different patient

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While the implications for SARM1 in regulating axonal fate are well-established, the sensing mechanisms of this protein complex toward NAD + , NMN, or even possibly toward other NAD + metabolites are not fully understood, and may suggest that also the other NAD + metabolites could regulate more biological processes than initially thought 54