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It spills over to MC3R and MC4R, triggering off-target effects

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Psychoneuroendocrinology 51:201208 Zidan A, Hedya SE, Elfeky DM, Abdin AA (2018) The possible anti-apoptotic and antioxidant effects of acetyl l-carnitine as an add-on therapy on a relapsing-remitting model of experimental autoimmune encephalomyelitis in rats

Separate inflammation models also suggest KPVs anti-inflammatory effects can be partly independent of MC1R/melanocortin receptor signaling, implying additional mechanisms