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This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries)

Researchers noticed that when this compound was transferred to waking animals, those animals entered deep sleep which is where the name comes from

Additionally, myofibroblasts (MyoF), a specialized subset of fibroblasts expressing extracellular matrix components like collagen, were found in higher numbers in the chronic kidney transplant rejection group, where elevated immune cell and MyoF levels correlated with increased rates of renal rejection and fibrosis

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It also helps coordinate daily fluctuations in hormone release, metabolism, and body temperature, among other physiological processes