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NICE guidance (NG28) on type 2 diabetes management does not include the combination of GLP-1 receptor agonists and DPP-4 inhibitors in its recommended treatment algorithms

In contrast, injections can show results in just a few days

Early response does not predict long-term success in either direction, so neither outcome should drive a decision at week two

1 Orforglipron availabililty Orforglipron clinical trials As of early 2024, Orforglipron is in Phase 3 clinical trials for both obesity and type 2 diabetes 2

Understanding the distinction between expected pharmacological effects and true gastroparesis is essential for safe use