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We strongly encourage you to speak to a healthcare provider to assess if this type of treatment is appropriate for your unique needs

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Side effects: While both can cause gastrointestinal issues, Ozempic is more associated with nausea, while metformin may cause more diarrhea

Importantly, Retatrutide's unique triple receptor agonismtargeting GLP-1, GIP, and glucagon receptorsappears well-tolerated, with adverse events largely consistent with known effects from the broader GLP-1 class, primarily mild gastrointestinal symptoms such as nausea, decreased appetite, and occasional diarrhea, typically resolving within a few weeks of initiation

No retatrutide trial has studied this middle-weight group directly