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Biochem Pharmacol 33 (12): 19291932

This pathway regulates: Protein synthesis (through mTORC1 activation) Cell survival and proliferation (Akt-dependent) Glucose metabolism Mitochondrial function MAPK/ERK Pathway Activation IGF-1 LR3 also activates the mitogen-activated protein kinase (MAPK/ERK) pathway, which regulates gene transcription and cell proliferation independent of mTOR signalling

For a broader look at this herb, see Cymbiotikas guide on what milk thistle is good for

Together, these nutrients help reduce the risk of cramps, fractures, and other bone-related problems

doi: 10.1016/j.phytochem.2022.113459 29 SilbersteinTHar-VardiIHarlevAFrigerMHamouBBaracTet al