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More serious but less common risks include pancreatitis, gallbladder disease, acute kidney injury (usually secondary to dehydration from gastrointestinal symptoms), and diabetic retinopathy complications, particularly in patients with pre-existing retinopathy who experience rapid improvement in blood glucose

Some genetic profiles show higher risk for micronutrient depletion during weight loss, helping PlexusDx providers recommend targeted supplementation from month one

These emergency criteria give patients and providers a clear threshold for escalation

Some fortified foods and supplements also contain B12