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In TRIUMPH-1, the first large Phase 3 trial (a large human trial with thousands of participants) in adults with obesity, retatrutide produced an average weight loss of 28.3% at the 12 mg dose after 80 weeks
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Clockwise also contains green tea extract, vitamin C, and alpha-lipoic acid, among other ingredients in smaller quantities
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This mitochondrial fission triggers an upregulation of CHAC1/BOTCH through the transcription factor NRF2 and ROS signaling, which in turn inhibits stem cell self-renewal and promotes cell differentiation (Khacho et al., 2016)
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