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Indeed, Yan et al (2020), exposed marine medaka to either MPs alone (100 g/L about 1 103 particles/mL 2.5 m fluorescent polystyrene), heavy metals (Cd 10 g/L, Pb 50 g/L, and Zn 100 g/L) or MPs and heavy metals combined (MPs 100 g/L, Cd 10 g/L, Pb 50 g/L, and Zn 100 g/L) for a month and concluded that, while all treatments changed the composition of the GM, the impact was highly dependent on the exposure-group as well as gender

It remains an investigational triple hormone-receptor agonist targeting the GIP, GLP-1, and glucagon receptors still moving through trials

This strategy helps manage costs while still providing access to effective treatments

This is an important planning consideration

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