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Its likely due to an indirect effect of the medication reducing appetite to a point where people dont eat enough, and their bodies enter starvation mode whereby metabolism effectively grinds to a halt to ensure sufficient energy delivery to vital organs

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Even small increases in movement, like walking more and taking the stairs instead of the elevator, can make a difference over time

Its youngest enrollees were 12 years old, and the protocol did not collect data that could be extrapolated to younger children