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When ActRIIA/B ligands bind to the receptor, they trigger receptor activation and intracellular signaling pathways through SMAD signaling pathways, which triggers transcriptional activation of a response element (RE), leading to NanoLuc Luciferase expression and bioluminescent signal
Visible collagen-driven changes emerge from week 6 to 8 and compound over 4 to 6 months of consistent bi-weekly use
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PMID: 48 SivasamiPElkinsCDiaz-SaldanaPPGossKPengAHamerskyMet al
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