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N Engl J Med 2025;392:427-437
Eli Lilly submitted the orforglipron NDA to the FDA in Q1 2026 following ATTAIN Phase 3 trial data showing 14.7% body weight reduction at 45mg positioning the worlds first oral small molecule GLP-1 receptor agonist for obesity for anticipated FDA approval in late 2026 or 2027
Stopping suddenly can trigger rapid appetite changes and blood sugar fluctuations, especially if you have diabetes
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