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Metabolic syndrome is often associated with disruption of circadian rhythm of systemic hemodynamics and cardiovascular disease
HGF/c-Met signaling pathways are uncontrolled in human cancer via overexpression of HGF or c-Met, gene amplification, mutational activation of c-Met, down-regulation of Met-targeted miRNA, binding to other ligands, autocrine signaling, or abnormally high HGF levels
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(1994b)
It has also been studied for wound healing and angiogenesis through the VEGFR2 pathway
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