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mito-TEMPO nitroxide radical concentration was obtained by double integration followed by Spin Count module (Bruker) and expressed as the nitroxide radical per g of protein

Available at: European Medicines Agency

Selected adults may increase to 7.2 mg after at least four weeks at 2.4 mg when additional weight reduction is clinically indicated. The 0.25 mg dose is the starter rather than the maintenance target

There are no toxicity levels

Clinically, GLP-1-based therapies offer the additional advantage of established cardiovascular protection and renal benefits, making them particularly attractive for the large proportion of MASLD patients with comorbid cardiovascular disease or type 2 diabetes