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One study explored mechanistic associations between GLP-1 functioning and mood disorders in humans: a post-mortem investigation showed that, compared with healthy controls, patients who had been diagnosed with mood disorders had lower expression of the gene encoding for GLP-1R in the dorso-lateral prefrontal cortex and the hippocampus, whereas this association was not observed in the brain tissue of people with schizophrenia 176
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39 YeL.HuangY.ZhaoL.LiY.SunL.ZhouY.et al (2013)
Descriptions of adverse effects are beyond the scope of this report
These salt bridges stabilize the ligand-receptor complex and improve binding affinity and activation, providing a robust template for the development of next-generation GLP-1R agonists
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