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The reduction in HbA 1c is independent of age (85), duration of T2D (87), or baseline HbA 1c, with meaningful reductions in all of the subgroups, even if the reduction is more significant in patients with higher HbA 1c at the baseline

or three or more additional risk factors for CVD

GLP-1 receptor agonists do not directly increase serotonin, so they carry minimal risk of triggering serotonin syndrome when combined with Zoloft at standard therapeutic doses

Lv C, Ma Q, Han B, Li J, Geng Y, Zhang X, Wang M (2018) Long-Term DL-3- n -Butylphthalide Treatment Alleviates Cognitive Impairment Correlate With Improving Synaptic Plasticity in SAMP8 Mice