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doi: 10.1038/s41577-019-0191-y 96 CuiGShimbaAJinJOgawaTMuramotoYMiyachiHet al
Serotonin Receptor Antagonists Targeting Altered Bowel Habits and Abdominal Pain 5-Hydroxytryptamine (5-HT), i.e., serotonin, is of importance in signaling pathways in the gut-brain interaction
It has always supported healthy mitochondrial function, iron metabolism, connective tissue, antioxidant defenses and hundreds of enzyme systems throughout the body
The molecule was first isolated from human plasma in the 1970s
Elevated resistin levels activate the c-Jun N-terminal kinase (JNK) pathway, which phosphorylates IRS-1 at serine residues, impairing its function and resulting in reduced glucose uptake and heightened insulin resistance (Kang et al., 2011)
