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In the case of LC, prior to the first step, there is the possibility of previous SARS-CoV-2 infection in individuals with weak HLA-II haplotypes against this virus and/or EBV

[1] If you experience persistent or concerning symptoms after starting B12 supplements, particularly skin changes or gastrointestinal issues, it is advisable to discuss these with your GP rather than assuming they are directly caused by vitamin excess

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Not enough to meaningfully affect hepatic stores during active alcohol metabolism