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This, in turn, doubles the capacity of the available growth factors to promote signaling cascades necessary for mitogenesis (cell division), motogenesis (promotion of cellular motility), morphogenesis (structural development), neurogenesis (growth and development of nervous tissue), production of stem cells, and protection of a wide range of cells against injury

For anyone dealing with chronic low-grade inflammation which is essentially 99% of people past mid-adulthood this systemic effect may be more valuable than mere cosmetic improvements

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The main rationale for cycling rather than continuous use involves conservative safety practices given limited long-term human data, cost management, and theoretical concerns about receptor desensitization with extended exposure