Melatonin has reassuring short- and medium-term safety data, with one review finding no evidence of dependency, tolerance, or rebound insomnia up to 12 months [7]

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Down regulation or loss of SULT1E1 could be to a certain extent responsible for growth of tumor in hormone sensitive cancers such as breast or endometrial cancer (Cole et al., 2010)
And there are meaningful, evidence-informed approaches to addressing them
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