tirzepatide.vs semaglutide Tirzepatide vs. Semaglutide: Which Weight Loss Drug Works Better? [May 2025 NEJM Study Explained] Tirzepatide vs. Semaglutide for Weight

Receptor-target and efficacy comparison: GLP-1 class agents | Agent | GLP-1 | GIP | Glucagon | Approval | Best trial weight loss | |---|---|---|---|---|---| | Liraglutide (Saxenda) | Yes | No | No | FDA-approved | 8.0% at 56 weeks (SCALE) | | Dulaglutide (Trulicity) | Yes | No | No | T2D only | 3.0 kg mean at 52 weeks | | Semaglutide (Wegovy) | Yes | No | No | FDA-approved | 14.9% at 68 weeks (STEP-1) | | Tirzepatide (Zepbound) | Yes | Yes | No | FDA-approved | 20.9% at 72 weeks (SURMOUNT-1) | | Retatrutide | Yes | Yes | Yes | Investigational | 24.2% at 48 weeks (Phase 2) | Liraglutide and Dulaglutide: Where They Fit Now Liraglutide (Saxenda, 3 mg once daily subcutaneous) was the first GLP-1 agonist approved specifically for obesity in the United States

In the analyses for PIONEER 2, 3 and 4, the results remained comparable to the base case analysis, with oral semaglutide 14 mg associated with a lower cost of control than all comparators for all four endpoints (Table 3)

While the risk of severe hypoglycemia is low when used as monotherapy, the risk may increase when combined with other diabetes medications that can cause hypoglycemia

Triclosan ACOG also recommends avoiding triclosan, an antibacterial ingredient found in many cosmetics and personal care products, as much as possible during pregnancy

Brahm NC, Yeager LL, Fox MD, et al