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Free Radical Res

The brain-access hypothesis and why it is contested One influential hypothesis for making sense of these mixed results, advanced by Christian Holscher, proposes that neuroprotective efficacy tracks a compounds ability to reach the brain

2025 Jul 22;4(8):EVIDoa2500173

GLP-1 receptors are found in the hypothalamus (appetite regulation), hippocampus (memory formation), brainstem (nausea responses), ventral tegmental area and nucleus accumbens (reward circuits), amygdala (emotional processing), prefrontal cortex (executive function), and substantia nigra (motor control)

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