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Anyway, at higher concentrations, like those deriving from a high-fat diet, primary and secondary BAs can reduce gut barrier integrity with their detergent properties, causing increased intestinal permeability and, thus, oxidative stress, DNA damage, and production of inflammatory cytokines, such as IL-6 and TNF-alpha, which promote inflammation and cause the inactivation of the FXR, thereby powering a pro-inflammatory state in the colon [25]
Tirzepatide and Retatrutide Do Dual/Triple Agonists Differ
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They found patients prescribed semaglutide (a glucagon-like peptide receptor, or GLP-1R) had a significantly lower risk for Alzheimers disease, compared to those who had taken any of seven other anti-diabetic medications, including other types of GLP-1R-targeting medications
IC 50 , Half-maximal inhibitory concentrations
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