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Wegovy FDAapproved since FDAapproved since June 2021 for chronic weight management in adults with obesity or overweight and at least one weight-related condition (e.g., hypertension, type 2 diabetes, or high cholesterol)

N Engl J Med 384(11):9891002 Davies M, Frch L, Jeppesen OK et al (2021) Semaglutide 24 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial

Rapid fat loss releases stored estrogen from adipose tissue

doi:10.1016/j.metabol.2013.08.003 Nauck MA et al

These levels generally reached a steady state after a few weeks and stayed there as long as the supplement was taken