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In this narrative review, we summarize the rationale, receptor biology, pharmacological mechanisms, inflammatory signaling hypotheses, clinical evidence, safety concerns, and implementation challenges related to GLP-1RA use in obesity-related KOA

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The gel diameter of the TGF-1-treated HTMCs was significantly lower than the negative controls, but the HTMCs cultured with glucaric acid did not significantly differ from the negative controls (Supplementary Fig