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Reported side effects are generally mild and include temporary gastrointestinal discomfort, headaches during initial use, occasional fatigue as the body adjusts, and rare nausea, especially when taken without food
At optimal concentrations, GHK-Cu increases mRNA production for collagen types I and III, elastin, proteoglycans, and glycosaminoglycans, while laboratory studies show that topical application for 12 weeks improves collagen production in 70% of subjects compared to 50% with vitamin C and 40% with retinoic acid
doi: 10.1093/nar/gku1276 298 JiangHCaoKFanCCuiXMaYLiuJ
Heidbreder C, De Witte P (1993) Ethanol differentially affects extracellular monoamines and GABA in the nucleus accumbens
its a physiological reality
