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Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation
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Occasional mild injection-site reactions (redness/itch) may occur with subcutaneous administration
New strategies designed to combat these disorders take advantage of the blood glucose-lowering and appetite-suppressing properties of GLP-1 and PYY(336), two peptides that are co-released from intestinal L-cells in response to ingested nutrients 19,20
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