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Patients should ensure their provider evaluates the risks and benefits carefully, especially if they have underlying conditions such as cardiovascular disease or worsening kidney disease
The ADA/EASD consensus report 4 highlights the use of DDP-4 inhibitors when intermediate efficacy for glucose lowering is required and where weight management goals would prefer a weight-neutral approach
There is limited evidence that substantially lower doses provide the same long-term results
GOV.UK news release, 24 October 2025
So if youre eating much less, not lifting, and low on protein, youre losing weight and muscle together
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