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When co-treated with Fer1, the PI uptake was effectively suppressed in the RSL3-treated 3D PTC spheroids, further reinforcing our previous findings of cytoprotective effects and ferroptosis pathway abrogation by Fer1 in RSL3-treated PTC cells in 2D
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The multiple cardiometabolic benefits include improving glycemic control, lipid profiles, blood pressure, inflammation, and hepatic steatosis
Many of these risks have been associated with cardiac remodeling due to damaged myocytes (heart muscle cells), and may impact surrounding tissues
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