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Fortunately, menopause treatment has come a long way
A comprehensive assessment including BMI, metabolic parameters, comorbidities, and previous treatment responses will inform whether these medications represent an appropriate option
Must keep refrigerated after opening, make sure cap is tightly secured
Compared with metformin (the first-line treatment for most patients), GLP-1 receptor agonists generally produce similar or slightly greater HbA1c reductions but with the added benefit of weight loss rather than weight neutrality
However, GLP-1 can activate GCGR in cells, and GCGR is able to reduce the number of docking granules by coupling and activating inhibitory GTP binding protein (Gi/o), thus inhibiting the secretion of glucagon, which is independent of GLP-1R (Gandasi et al., 2024)
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