To further characterize compound engagement of TGR in ex vivo worms using an orthogonal assay, inhibition of TGR activity in newly transformed schistosomula (NTS, skin-stage worms) was assessed using a TrxR-selective fluorescent probe 43,44 , TRFS-Green
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Activated immune cells infiltrating the islets release cytokines such as interleukin-1 beta (IL-1) and interferon gamma (IFN-), which further stimulate mitochondrial ROS production in beta cells [85]
Wang et al., 2015)
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