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This is why GLP-1 receptor agonists are so promising they don't just target one mediator like antihistamines do
Semaglutide has demonstrated the highest percentage of weight loss in obese adults without type 2 diabetes, with reductions of approximately 15% of initial weight at 68 weeks (Wilding et al., 2021)
Elevated resting heart rate is an independent risk factor for adverse outcomes in heart failure, and beta-blocker therapy to reduce heart rate is a cornerstone of HFrEF management
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