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Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis
It also causes the skin to lighten by converting melanin to a lighter color and deactivating the enzyme tyrosinase, which helps produce the pigment 2
This success led to the development of exenatide, the first GLP-1 receptor agonist approved by the FDA for the treatment of diabetes (in 2004)
It most commonly affects the central facial skin on the nose, cheeks, and forehead
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