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In cases where plans had both, 86% of policy pairs were concordant (same criteria) but 14% differed, often because step-therapy rules or prescriber requirements did not align ( [16] )

"Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin - A pilot clinical, histologic, and ultrastructural study"

Because the article frames this as an absence of data rather than a finding of safety or harm, which is exactly why caution is the default

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