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The molecule carries an -aminoisobutyric acid (Aib) substitution at position 2 that blocks DPP-IV cleavage, conferring complete resistance to the proteolytic step that inactivates native incretins within minutes
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A quick safety note that applies to every GLP-1: Trulicity carries a boxed warning about thyroid C-cell tumors and should not be used by people with a personal or family history of medullary thyroid carcinoma or MEN 2
You can mix them into sauces, roast them for texture, or even use spiralized veggies like zucchini noodles ("zoodles") as a full pasta replacement
No, back pain is not listed as a common or characteristic side effect in FDA prescribing information for GLP-1 receptor agonists
