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A mediation analysis of the EMPA-REG OUTCOME trial

The researchers concluded that IGF-I promotes an average increase of 15% in muscle mass and a 14% increase in strength in muscle tissue

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Diabetes Obes Metab 25(1):1835 Webster CM et al (2023) Potential contributors to variation in weight-loss response to liraglutide

Verdict: Cheap but ineffective for most people