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CB1R blockade ameliorates the ATF6 arm of the unfolded protein response to cytokines in human ex vivo islets It has been suggested that NO induces beta cell death through the activation of endoplasmic reticulum (ER) stress [34], and ER stress in beta cells precedes type 1 diabetes onset [35]
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And this is important both in terms of thinking about what effects you're going to get of taking a given peptide, if you decide to do that, as well as potential side effects, as well as things like how to adjust dosage and how long to take a peptide, whether or not to cycle the peptide, et cetera
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