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We have learned that many of the GLP-1 benefits in humans are also weight-loss independent, which is fascinating. Even albiglutide (Tanzeum, GlaxoSmithKline), which was taken off the market because it wasnt as good as other GLP-1s at reducing glucose and weight, reduced risk for major adverse cardiovascular events (MACE) by 22% compared with placebo despite no difference between the groups in weight loss, he said
Clinical trials with GLP-1 receptor agonists consistently demonstrate significant weight loss, with higher doses (such as semaglutide 2.4 mg weekly) producing approximately 15% average weight loss in adults without diabetes in clinical trials (somewhat less in type 2 diabetes) when combined with lifestyle modification
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