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The role of membrane proteolysis, particularly through pathways such as ERAD and intramembrane proteolysis, is crucial for cardiovascular health

How Do We Get It

Guo, J., et al

The molecule is structurally modified with an N-terminal trans-3-hexenoyl group, which dramatically reduces its susceptibility to dipeptidyl peptidase IV (DPP-IV) degradation, the enzyme that breaks down natural GHRH

Moreover, adequate safety margins were observed in repeat-dose rat and monkey toxicology studies, which supported advancing PF-06882961 to human clinical studies