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As weight decreases and insulin sensitivity improves, glucose levels may drop, potentially necessitating adjustments to other diabetes medications to prevent hypoglycaemia
New England Journal of Medicine , 384(11), 989-1002
Risk is still graver for an additional cohort with CAD determined to be refractory to all available treatments, with numbers estimated to reach 1.8 million in prevalence and an additional 50,000 in annual incidence in the United States
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But berberine's glucose-lowering is glucose-dependent, meaning it tends to work harder under hyperglycemic conditions
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