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F., Asrar, M., Selamoglu, Z., Ji, X.-Y., Adem, ., & Sarker, S

Nonetheless, when administered at excessively high concentrations, alterations in hepatic and renal functionality may occur

and physiology 46 (8), 780787

Your prescriber may recommend staying on a current dose longer if: You are experiencing ongoing nausea or vomiting You feel dizzy or fatigued You are losing weight steadily without needing an increase You prefer to remain on a well-tolerated dose Increasing too quickly can reduce adherence and make side effects harder to manage

Improving tolerability is not optional