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The peak concentrations of radioactivity in the kidney, liver, stomach wall, thymus, and spleen were significantly higher than those in the plasma

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A 2025 real-world safety comparison found the two drugs had distinct safety profiles, rather than one being safer overall

This broad expression spectrum increases the risk of off-target accumulation, which may exacerbate GLP-1RA-associated side effects including nausea, delayed gastric emptying, tachycardia, and arrhythmias