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Theyve made such a splash that the journal Science named GLP-1 drugs the 2023 Breakthrough of the Year

On rest days, return to your standard calorie target

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There will be challenges with testing these interventions

This may include: BMI 30, or 27 with related conditions Documented attempts at calorie reduction Exercise or physical activity history Behavioral or lifestyle counseling These requirements do not need to be perfectbut they do need to be documented