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doi: 10.1186/s12933-022-01604-7 130 KaragiannisTAvgerinosILiakosADel PratoSMatthewsDRTsapasAet al

During the titration phase, the dosage is increased by 2.5 mg increments every 4 weeks

The key finding was that plasma concentrations in patients taking 8 mg of retatrutide (approximately 182 nanomolar) exceeded the effective concentrations observed in the laboratory, suggesting these cardiac effects are clinically relevant at therapeutic doses