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Allergic Reactions: Itching, rash, hives, shortness of breath, or swelling of the face, lips, tongue, or throat
In addition to the US FDA approved GLP-1RAs, there are GLP1/glucagon dual agonists (Cotadutide, BI 456906), GIP/GLP1 dual agonists (Tirzepatide, GIP/GLP peptide I and II), GIP/GLP1/glucagon tri-agonists (HM15211, GGG tri-agonist) and GLP1R agonists (Efpeglenatide, Rybelsus) currently in phase 1- III clinical trials for T2D, obesity, and NASH (MASH) treatments (12)
They are generally safe and work well for those who are deficient
Conversely, semaglutide-focused studies in older adults have accelerated in recent years and appear to be highly promising [59,60,61]
